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Mitochondrial neurogastrointestinal encephalomyopathy
3 OMIM references -
3 associated genes
28 connected diseases
No signs/symptoms info
Disease Type of connection
Autosomal dominant progressive external ophthalmoplegia
Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
Alpers syndrome
Autosomal recessive progressive external ophthalmoplegia
Kearns-Sayre syndrome
Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy
Recessive mitochondrial ataxia syndrome
Sensory ataxic neuropathy - dysarthria - ophthalmoparesis
Spinocerebellar ataxia with epilepsy
B-cell chronic lymphocytic leukemia
Adrenocortical carcinoma
Essential thrombocythemia
Familial pancreatic carcinoma
Giant cell glioblastoma
Gliosarcoma
Li-Fraumeni syndrome
Papilloma of choroid plexus
Precursor B-cell acute lymphoblastic leukemia
Dedifferentiated liposarcoma
Well-differentiated liposarcoma
Ataxia-telangiectasia
Ataxia-telangiectasia variant
Combined cervical dystonia
Mantle cell lymphoma
Burkitt lymphoma
Hyper-IgM syndrome type 2
Precursor T-cell acute lymphoblastic leukemia
Spinocerebellar ataxia type 26
Synonym(s):
- MNGIE
Classification (Orphanet):
- Inborn errors of metabolism
- Rare eye disease
- Rare gastroenterologic disease
- Rare genetic disease
- Rare neurologic disease
Classification (ICD10):
- Diseases of the nervous system -
Epidemiological data:
Class of prevalence: 1-9 / 1 000 000
Average age onset: adolescence / young
Average age of death: adult
Type of inheritance: autosomal recessive
External references:
3 OMIM references -
No MeSH references
Gene symbol UniProt reference OMIM reference
POLG P54098174763
RRM2B Q7LG56604712
TYMP P19971131222
No signs/symptoms info available.